Sentinel Flea Tabs
The palatable once-a-month prescription tablet
that prevents heartworm disease and flea populations in dogs
SENTINEL Flavor Tabs also control
flea populations and adult hookworms, and remove and control
adult roundworm and whipworm infections in dogs and puppies.
U.S. Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
SENTINEL Flavor Tabs are available in four tablet sizes in
color-coded packages for oral administration to dogs and puppies
according to their weight. (See Dosage Section.) Each tablet
is formulated to provide a minimum of 0.23 mg/lb (0.5 mg/kg)
of milbemycin oxime and 4.55 mg/lb (10 mg/kg) body weight
Milbemycin oxime consists of the
oxime derivatives of 5-didehydromilbemycins in the ratio of
approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7,
MW 541.68). Milbemycin oxime is classified as a macrocyclic
Lufenuron is a benzoylphenylurea
derivative with the following chemical composition: N-[2,5-dichloro-
- difluorobenzamide (C17 H8 CI2F8N2O3 ,MW511.15). Benzoylphenylurea
compounds, including lufenuron, are classified as insect development
Mode of Action
Milbemycin oxime, one active ingredient in SENTINEL Flavor
Tabs, is a macrocyclic anthelmintic which is believed to act
by interfering with invertebrate neurotransmission. Milbemycin
oxime eliminates the tissue stage of heartworm larvae and
the adult stage of hookworm (Ancylostoma caninum), roundworm
(Toxocara canis and Toxascarisleonina) and whipworm (Trichuris
vulpis) infestations when administered orally according to
the recommended dosage schedule.
Lufenuron, the other active ingredient in SENTINEL Flavor
Tabs, is an insect development inhibitor which breaks the
flea life cycle by inhibiting egg development. Lufenuron's
mode of action is interference with chitin synthesis, polymerization
and deposition. Lufenuron has no effect on the adult flea.
After biting a lufenuron-treated dog, the female flea ingests
a blood meal containing lufenuron which is subsequently deposited
in her eggs. Lufenuron prevents most flea eggs from hatching
or maturing into adults and thus prevents and controls flea
populations by breaking the life cycle. (See Efficacy.)Indications
SENTINEL Flavor Tabs are indicated for use in dogs and puppies,
four weeks of age and older, and two pounds body weight or
greater. SENTINEL Flavor Tabs are also indicated for the prevention
of heartworm disease caused by Dirofilaria immitis, for the
prevention and control of flea populations, the control of
adult Ancylostoma caninum (hookworm), and the removal and
control of adult Toxocara canis and Toxascaris leonina (round-worm)
and Trichuris vulpis (whipworm) infections.
Lufenuron controls flea populations
by preventing the development of flea eggs and does not kill
adult fleas. Concurrent use of insecticides may be necessary
for adequate control of adult fleas.
Do not use in puppies less than four weeks
of age and less than two pounds of body weight. Prior to administration
of SENTINEL Flavor Tabs, dogs should be tested for existing
heartworm infections. Infected dogs should be treated to remove
adult heartworms and microfilariae prior to initiating treatment
with SENTINEL Flavor Tabs. Mild, transient hypersensitivity
reactions manifested as labored respiration, vomiting, salivation
and lethargy have been noted in some treated dogs carrying
a high number of circulating microfilariae. These reactions
are pre-sumably caused by release of protein from dead or
SENTINEL Flavor Tabs immediately break the flea life cycle
by inhibiting egg development. However, pre-existing flea
populations may continue to develop and emerge after treatment
with SENTINEL Flavor Tabs. Based on results of clinical studies,
this emergence generally occurs during the first 30-60 days.
Therefore, noticeable control may not be observed until several
weeks after dosing when a pre-existing infestation is present.
Cooler geographic areas may have longer lag periods due to
a prolonged flea life cycle. The concurrent use of conventional
insecticidal products may be employed depending on the severity
of the infestation.
If a SENTINEL Flavor Tabs-treated dog comes in contact with
a flea-infested environment, adult fleas may infest the treated
animal. These adult fleas are unable to produce viable offspring.
Depending on the severity of infestation, the temporary use
of conventional adulticides in an integrated flea control
program may be necessary to control these adult fleas.
Adequate flea control may not be achieved in dogs that have
repeated exposure to flea-infested animals or environments.
Efficacy: Milbemycin Oxime
Milbemycin oxime provided complete protection against heartworm
infection in both controlled laboratory and clinical trials.
In laboratory studies, a single dose of milbemycin oxime at
0.5 mg/kg was effective in removing roundworm, hookworm and
whipworm. In well-controlled clinical trials, milbemycin oxime
was also effective in removing round-worms and whipworms and
in controlling hookworms.
flea eggs and larvae from developing. This breaks the flea
life cycle at its base, and effectively controls the flea
-brand products is the longest-lasting, most complete product
for controlling fleas and ticks. FRONTLINE for dogs and cats
is highly effective, easy to use and provides superior, guaranteed
protection. What's more, FRONTLINE is available in three convenient
formulations to make it easy for you to protect your pet.
-there are five nasty parasites that
threaten your dog: fleas, heartworms, hookworms, roundworms
and whipworms. Only SENTINEL® Flavor Tabs® can protect
against all five parasites at once.
GUARD -Heartworm disease is 100% preventable
with HEARTGARD Plus! All you have to do to protect your dog
from the threat of this deadly infection is to give HEARTGARD
Plus once a month and use as otherwise directed.
-prevents deadly heartworm disease,
while it protects your dog against roundworms, hookworms (A.
Caninum) and whipworms.
-Because it works so fast, Advantage
provides relief from fleas within minutes. Advantage is proven
to stop fleas from biting in 3 - 5 minutes after application.
Advantage kills 98-100 percent of fleas within 12 hours of
application. In addition, one convenient treatment lasts for
up to one month.
-Revolution is the first-ever FDA approved, topically-applied
medication for both dogs and cats that: Prevents heartworm
(Dirofilaria immitis) disease, Kills adult fleas (Ctenocephalides
felis) and prevents their eggs from hatching, Treats and controls
ear mites (Otodectes cynotis), Treats and controls sarcoptic
mange (Sarcoptes scabiei) in dogs, Treats hookworm (Ancylostoma
tubaeforme) and roundworm (Toxocara cati) in cats, Controls
American dog tick (Dermacentor variabilis) infestations in
-Is your dog being attacked by mosquitoes,
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Links to Flea and Parasite Medication Manufacturers>>