DOG MEDS:

Advantage Program Tabs K9 Advantix Frontline Plus Interceptor Revolution Heartguard

Sentinel Flea Tabs

The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies.

SENTINEL Flavor Tabs also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies.

Caution
U.S. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description
SENTINEL Flavor Tabs are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. (See Dosage Section.) Each tablet is formulated to provide a minimum of 0.23 mg/lb (0.5 mg/kg) of milbemycin oxime and 4.55 mg/lb (10 mg/kg) body weight of lufenuron.

Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68). Milbemycin oxime is classified as a macrocyclic anthelmintic.

Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-[2,5-dichloro- 4-(1,1,2,3,3,3,-hexafluoropropoxy)- phenylaminocarbonyl]-2,6 - difluorobenzamide (C17 H8 CI2F8N2O3 ,MW511.15). Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs).

Mode of Action
Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascarisleonina) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule.

Lufenuron, the other active ingredient in SENTINEL Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Lufenuron's mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron has no effect on the adult flea. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. (See Efficacy.)Indications
SENTINEL Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. SENTINEL Flavor Tabs are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (round-worm) and Trichuris vulpis (whipworm) infections.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of insecticides may be necessary for adequate control of adult fleas.

Precautions
Do not use in puppies less than four weeks of age and less than two pounds of body weight. Prior to administration of SENTINEL Flavor Tabs, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL Flavor Tabs. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are pre-sumably caused by release of protein from dead or dying microfilariae.
SENTINEL Flavor Tabs immediately break the flea life cycle by inhibiting egg development. However, pre-existing flea populations may continue to develop and emerge after treatment with SENTINEL Flavor Tabs. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of conventional insecticidal products may be employed depending on the severity of the infestation.

If a SENTINEL Flavor Tabs-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. Depending on the severity of infestation, the temporary use of conventional adulticides in an integrated flea control program may be necessary to control these adult fleas.
Adequate flea control may not be achieved in dogs that have repeated exposure to flea-infested animals or environments.

Efficacy: Milbemycin Oxime
Milbemycin oxime provided complete protection against heartworm infection in both controlled laboratory and clinical trials.
In laboratory studies, a single dose of milbemycin oxime at 0.5 mg/kg was effective in removing roundworm, hookworm and whipworm. In well-controlled clinical trials, milbemycin oxime was also effective in removing round-worms and whipworms and in controlling hookworms.

Preventitive Medications:

PROGRAM -prevent flea eggs and larvae from developing. This breaks the flea life cycle at its base, and effectively controls the flea population.

FRONTLINE -brand products is the longest-lasting, most complete product for controlling fleas and ticks. FRONTLINE for dogs and cats is highly effective, easy to use and provides superior, guaranteed protection. What's more, FRONTLINE is available in three convenient formulations to make it easy for you to protect your pet.

SENTINEL -there are five nasty parasites that threaten your dog: fleas, heartworms, hookworms, roundworms and whipworms. Only SENTINEL® Flavor Tabs® can protect against all five parasites at once.

HEART GUARD -Heartworm disease is 100% preventable with HEARTGARD Plus! All you have to do to protect your dog from the threat of this deadly infection is to give HEARTGARD Plus once a month and use as otherwise directed.

INTERCEPTOR -prevents deadly heartworm disease, while it protects your dog against roundworms, hookworms (A. Caninum) and whipworms.

ADVANTAGE -Because it works so fast, Advantage provides relief from fleas within minutes. Advantage is proven to stop fleas from biting in 3 - 5 minutes after application. Advantage kills 98-100 percent of fleas within 12 hours of application. In addition, one convenient treatment lasts for up to one month.

REVOLUTION -Revolution is the first-ever FDA approved, topically-applied medication for both dogs and cats that: Prevents heartworm (Dirofilaria immitis) disease, Kills adult fleas (Ctenocephalides felis) and prevents their eggs from hatching, Treats and controls ear mites (Otodectes cynotis), Treats and controls sarcoptic mange (Sarcoptes scabiei) in dogs, Treats hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) in cats, Controls American dog tick (Dermacentor variabilis) infestations in dogs.

K9ADVANTIX -Is your dog being attacked by mosquitoes, ticks and fleas? If you are looking for information on the only product that can keep mosquitoes, ticks and fleas off your four-legged friend then you’ve come to the right place. At K9Advantix.com we’ll provide you with the information you’ll need to rid your dog of these pests forever!

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