INTERCEPTOR Flavor Tabs
are the only monthly preventive that protects against four
parasites all at once. INTERCEPTOR prevents deadly heartworm
disease, while it protects your dog against adult roundworms,
adult hookworms (A. caninum) and whipworms.
Information for dosing dogs
The palatable once-a-month tablet that prevents heartworm
disease, controls adult hookworm, and removes and controls
adult roundworm and whipworm infections in dogs and puppies.
U.S. Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
INTERCEPTOR (milbemycin oxime) Flavor Tabs are available in
four tablet sizes in color-coded packages for oral administration
to dogs and puppies. Each tablet is formulated to provide
a minimum of 0.23 mg/lb (0.5 mg/kg) body weight of milbemycin
oxime. Milbemycin oxime consists of the oxime derivatives
of 5-didehydromilbemycins in the ratio of approximately 80%
A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68).
INTERCEPTOR Flavor Tabs are indicated for use in the prevention
of heartworm disease caused by Dirofilaria immitis, the control
of adult Ancylostoma caninum (hookworm), and the removal and
control of adult Toxocara canis and Toxascaris leonina (roundworms)
and Trichuris vulpis (whipworm) infections in dogs and in
puppies four weeks of age or greater, and two pounds body
weight or greater.
INTERCEPTOR Flavor Tabs are given orally, once a month, at
the recommended minimum dosage rate of 0.23 mg milbemycin
oxime per pound of body weight (0.5 mg/kg).
INTERCEPTOR Flavor Tabs are palatable and most dogs will consume
the tablet willingly when offered by the owner. As an alternative,
the dual-purpose tablet may be offered in food or administered
as other tablet medications. Watch the dog closely following
dosing to be sure the entire dose has been consumed. If it
is not entirely consumed, redose once with the full recommended
dose as soon as possible.
INTERCEPTOR Flavor Tabs must be administered
monthly, preferably on the same date each month. The first
dose should be administered within one month of the dog's
first exposure to mosquitoes and monthly thereafter until
the end of the mosquito season. If a dose is missed and a
30-day interval between dosing is exceeded, administer INTERCEPTOR
Flavor Tabs immediately and resume the monthly dosing schedule.
If INTERCEPTOR Flavor Tabs replaces diethylcarbamazine
(DEC) for heartworm prevention, the first dose must be given
within 30 days after the last dose of DEC.
Palatability trials conducted in 244 dogs from 10 different
U.S. veterinary practices demonstrated that INTERCEPTOR Flavor
Tabs were willingly accepted from the owner by over 95% of
dogs. The trial was comprised of dogs representing 60 different
breeds and both sexes, with weights ranging from 2.1 lbs.
to 143.3 lbs., and ages ranging from 8 weeks to 15 years.
Do not use in puppies less than four weeks
of age and less than two pounds of body weight. Prior to initiation
of the INTERCEPTOR Flavor Tabs treatment program, dogs should
be tested for existing heartworm infections. Infected dogs
should be treated to remove adult heartworms and microfilariae
prior to initiating treatment with INTERCEPTOR Flavor Tabs.
Mild, transient hypersensitivity reactions manifested as labored
respiration, vomiting, salivation and lethargy, have been
noted in some treated dogs carrying a high num-ber of circulating
microfilariae. These reactions are presumably caused by release
of protein from dead or dying microfilariae.
The following adverse reactions have been reported following
the use of INTERCEPTOR: Depression/ lethargy, vomiting, ataxia,
anorexia, diarrhea, convulsions, weakness and hypersalivation.
INTERCEPTOR Flavor Tabs eliminate the tissue stage of heartworm
larvae and the adult stage of hookworm (Ancylostomacaninum),
roundworms (Toxocara canis, Toxascaris leonina) and whipworm
(Trichuris vulpis ) infestations when administered orally
according to the recommended dosage schedule. The anthelmintic
activity of milbemycin oxime is believed to be a result of
interference with invertebrate neurotransmission.
INTERCEPTOR has been tested safely in over 75 different breeds
of dogs, including collies, pregnant females, breeding males
and females, and puppies over two weeks of age. In well-controlled
clinical field studies, 786 dogs completed treatment with
milbemycin oxime. Milbemycin oxime was used safely in animals
receiving frequently used veterinary products such as vaccines,
anthelmintics, antibiotics, steroids, flea collars, shampoos
Two studies in heartworm-infected dogs were
conducted which demonstrated mild, transient hypersensitivity
reactions in treated dogs with high microfilaremia counts
(see Precautions for reactions observed). Safety studies in
pregnant dogs demonstrated that high doses (1.5 mg/kg = 3X)
of milbemycin oxime given in an exaggerated dosing regimen
(daily from mating through weaning), resulted in measurable
concentrations of the drug in milk. Puppies nursing these
females which received exaggerated dosing regimens demonstrated
milbemycin-related effects.These effects were directly attributable
to the exaggerated experimental dosing regimen. The product
is normally intended for once-a-month administration only.
Subsequent studies included using 3X daily from mating to
one week before weaning and demonstrated no effects on the
pregnant females or their litters. A second study where pregnant
females were dosed once at 3X the monthly use rate either
before, on the day of or shortly after whelping resulted in
no effects on the puppies.
Some nursing puppies, at 2, 4, and 6 weeks
of age, given greatly exaggerated oral INTERCEPTOR doses (9.6
mg/kg = 19X) exhibited signs typified by tremors, vocalization
and ataxia. These effects were all transient and puppies returned
to normal within 24 to 48 hours. No effects were observed
in puppies given the recommended dose of INTERCEPTOR (0.5
mg/kg). This product has not been tested in dogs less than
1 kg weight.
A rising-dose safety study conducted in roughcoated
collies manifested a clinical reaction consisting of ataxia,
pyrexia and periodic recumbency in one of fourteen dogs treated
with milbemycin oxime at 12.5 mg/kg (25X monthly use rate).
Prior to receiving the 12.5 mg/kg dose (25X monthly use rate)
on day 56 of the study, all animals had undergone an exaggerated
dosing regimen consisting of 2.5 mg/kg milbemycin oxime (5X
monthly use rate) on day 0, followed by 5.0 mg/kg (10X monthly
use rate) on day 14 and 10.0 mg/kg (20X monthly use rate)
on day 32. No adverse reactions were observed in any of the
collies treated with this regimen up through the 10.0 mg/kg
(20X monthly use rate) dose.
INTERCEPTOR Flavor Tabs are available in four tablet sizes
(see Dosage section), formulated according to the weight of
the dog. Each tablet size is available in color-coded packages
of 6 or 12 tablets each, which are packaged 10 per display
INTERCEPTOR Flavor Tabs should be stored at room temperature,
between 59° and 86°F (15-30°C).
Keep this and all drugs out of the reach of
flea eggs and larvae from developing. This breaks the flea
life cycle at its base, and effectively controls the flea
-brand products is the longest-lasting, most complete product
for controlling fleas and ticks. FRONTLINE for dogs and cats
is highly effective, easy to use and provides superior, guaranteed
protection. What's more, FRONTLINE is available in three convenient
formulations to make it easy for you to protect your pet.
-there are five nasty parasites that
threaten your dog: fleas, heartworms, hookworms, roundworms
and whipworms. Only SENTINEL® Flavor Tabs® can protect
against all five parasites at once.
GUARD -Heartworm disease is 100% preventable
with HEARTGARD Plus! All you have to do to protect your dog
from the threat of this deadly infection is to give HEARTGARD
Plus once a month and use as otherwise directed.
-prevents deadly heartworm disease,
while it protects your dog against roundworms, hookworms (A.
Caninum) and whipworms.
-Because it works so fast, Advantage
provides relief from fleas within minutes. Advantage is proven
to stop fleas from biting in 3 - 5 minutes after application.
Advantage kills 98-100 percent of fleas within 12 hours of
application. In addition, one convenient treatment lasts for
up to one month.
-Revolution is the first-ever FDA approved, topically-applied
medication for both dogs and cats that: Prevents heartworm
(Dirofilaria immitis) disease, Kills adult fleas (Ctenocephalides
felis) and prevents their eggs from hatching, Treats and controls
ear mites (Otodectes cynotis), Treats and controls sarcoptic
mange (Sarcoptes scabiei) in dogs, Treats hookworm (Ancylostoma
tubaeforme) and roundworm (Toxocara cati) in cats, Controls
American dog tick (Dermacentor variabilis) infestations in
-Is your dog being attacked by mosquitoes,
ticks and fleas? If you are looking for information on the
only product that can keep mosquitoes, ticks and fleas off
your four-legged friend then you’ve come to the right
place. At K9Advantix.com we’ll provide you with the
information you’ll need to rid your dog of these pests
Links to Flea and Parasite Medication Manufacturers>>